Managing Mounjaro Side Effects: Evidence-Based Solutions
Practical, doctor-approved strategies for preventing and managing common Mounjaro side effects including nausea, constipation, and gastrointestinal discomfort.
Medical Team
December 16, 2025
Understanding and Managing GLP-1 Side Effects
While Mounjaro and other GLP-1 receptor agonists offer remarkable metabolic benefits, gastrointestinal side effects are common, especially during dose escalation. Understanding why these occur and how to manage them ensures better treatment adherence and quality of life.
Nausea: The Most Common Challenge
Nausea affects 15-30% of users, most commonly during dose increases. Prevention strategies include slow dose titration, timing injections before bed, eating smaller meals, and choosing bland foods.
Constipation Management
Comprehensive approaches include proper hydration, gradual fiber increases, regular physical activity, and appropriate use of supplements or medications when needed.
Long-Term Tolerance
Most side effects diminish significantly after 8-12 weeks as your body adapts to the medication.
Medical Disclaimer
This article is for educational purposes only and should not be considered medical advice. Always consult with qualified healthcare professionals before making decisions about your health or treatment.